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In addition to contributions to the field of cell biology, Snyder’s laboratory has invented a number of novel systems-wide and genomics technologies, and his laboratory has used these to make fundamental biological discoveries.

At a time when most laboratories were studying one or a limited number of genes at a time, Snyder’s laboratory set up the first large scale systems project to study all yeast genes and proteins simultaneously using a transposon tagging strategy to analyze gene expression, protein localization and gene disruption . This was the first large-scale systems analysis of genes and proteins in any organism and launched the field of functional genomics. The libraries and approaches were widely utilized by many laboratories around the world and launched the concept of open sharing and reagents, prior to publication. With Dr. Patrick Brown’s laboratory, the Snyder laboratory invented ChIP-chip (which they later morphed into ChIP-seq to carry out the first genome wide mapping of transcription factor binding sites. Initially established for yeast, they later applied the methods to humans . This method was foundational for multiple multicenter consortia projects including the Encyclopedia of DNA Elements project (ENCODE; ).

He has authored a book for a general audience: "Genomics and Personalized Medicine: What Everyone Needs to Know". Oxford University Press. 2016. It describes the utility of genome sequencing, other omics technologies and big data in medicine and prospects for the future.

He has been listed in the "Most Cited Scientists since 2014" and has given many distinguished and named lectureships. Since 2009 these include:

In 2009 Snyder moved to Stanford University to Chair the Genetics Department and to direct the Center for Genomics and Personalized Medicine. Since 2010 the U.S. News & World Report has ranked Stanford University first or tied for first in Genetics, Genomics and Bioinformatics.

Using the same in-depth omics approaches he applied to yeast, upon his move to Stanford in 2009, Snyder began to apply systems-wide analysis to human health . The Snyder laboratory carried out the first deep longitudinal profiling of one person using multi-'omics technologies (genomics, transcriptomics, proteomics, metabolomics, etc.). This deep profiling used genomics for the first time to predict disease risk and follow disease onset at a level not previously achieved . This work was recognized as a landmark paper in the journal Cell's 40th anniversary celebration in 2012. This approach of collecting longitudinal deep data on humans is now being applied by many groups worldwide. The Snyder lab has recently demonstrated that self-tracking using wearable biosensor can be used for monitoring health and illness . Together these studies demonstrate the power of using longitudinal tracking and big data to manage human health.

Snyder was elected and has served as President of US Human Proteome Organization (2006–2008) and Human Proteome Organization (2017-2018). He has served on numerous scientific advisory committees (e.g. EMBL Scientific Advisory Committee) and is on the Genetics Society Board of Directors (2006–2009). He has organized many scientific meetings.

Snyder has been Principal Investigator of Center of Excellence in the Genome Sciences (CEGS) (2001–2011), NIH Training Grants in Genomics and Proteomics (first at Yale, now at Stanford) (2004–present), and is coDirector of the CIRM Center for Stem Cell Genomics and Director or the Center for Genome of Gene Regulation. He has been a Principal Investigator in the ENCODE project since its inception in 2003.

He was promoted to Associate Professor with tenure in 1994, and when the Biology Department split in the Molecular, Cellular and Developmental Biology (MCDB) and Ecology and Evolutionary Biology, he became chair of the new MCDB department. During his six years as chair the Department doubled in size and tripled in research funding. He was also the Director for the Center for Genomics and Proteomics at Yale University.

Snyder moved to Yale as an Assistant Professor in 1986 in the Department of Biology. His laboratory worked on chromosome segregation and cell polarity for which he discovered a number of important genes involved in these processes . His laboratory proposed the first models by which eucaryotes select sites of cell growth .

Michael Snyder (born 1955) is an American genomicist, systems biologist, and entrepreneur. He is the Stanford B. Ascherman Professor and Chair of Genetics and Director of Genomics and Personalized Medicine at Stanford University School of Medicine.

Snyder was born 1955 and grew up outside of Pottstown, Pennsylvania. His father, Kermit Snyder, was an accountant and his mother, Phyllis Snyder, was an elementary school teacher. Snyder attended Owen J Roberts High school in Pottstown, Pennsylvania. He won a Bausch & Lomb science award and attended the University of Rochester, NY where he received a B.A. in Chemistry and Biology. Upon graduation Snyder worked as a research assistant with Karl Drlica at the University of Rochester.