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Crislip has been on the Top Docs list published by Portland Monthly magazine several times, most recently in 2014. U.S. News & World Report listed him as a Top U.S. Physician in 2012. The residents at his hospital also named him "Attending Most Likely to Tell It Like It Is."

Several organizations that promote science and skepticism have invited Crislip to give lectures about alternative medicine and the anti-vaccine movement. He has spoken at The Amaz!ng Meeting three times, most recently in 2013. In June 2010 he gave a talk called "The Vaccine Pseudo-Controversy" for the Center for Inquiry Portland. In November 2013 he spoke at a meeting of Oregonians for Science and Reason on the topic of "Supplement, Complementary and Alternative Medicine Myths." He was also a featured speaker at the QED Conference in Manchester, England in April 2014.

Crislip has been producing the Gobbet o' Pus podcast since 2009. The show features short discussions of interesting cases he has encountered in his medical practice and other topics of interest to infectious disease specialists. A new episode is released every few days.

Skeptic magazine published an article by Crislip in 2008 titled "Near Death Experiences and the Medical Literature," in which he criticized a Lancet article that reported on near-death experiences without considering all the physiological factors that may have accounted for patients' subjective experiences.

Each episode of QuackCast features Crislip delivering a monologue about a topic related to medicine, usually a critique of an alternative medicine practice or set of beliefs. He was inspired to create his own science-based medicine show after listening to the popular podcast Slacker Astronomy. The first episode of QuackCast was released on 5 May 2006, and other episodes have been released intermittently since then. The podcast has won three Podcast Awards in the Health/Fitness category, for the years 2009, 2010, and 2011.

PusCast (also known as Persiflagers Infectious Disease PusCast) is a bimonthly review of the infectious disease literature. Crislip has been producing this podcast since November 2006.

Crislip was born in Cleveland, Ohio. He attended the University of Oregon from 1979 to 1983, where he earned a Bachelor of Science degree in physics. He then earned a Doctor of Medicine (MD) degree at the Oregon Health & Science University School of Medicine in 1983. He completed an internship and residency at Hennepin County Medical Center in Minneapolis in 1986, followed by a fellowship at Harbor–UCLA Medical Center. He is currently a board-certified infectious disease specialist at several medical centers in the Portland area.

Mark Alden Crislip (born April 25, 1957) is an infectious disease doctor in Portland, Oregon and chief of infectious diseases at Legacy Health hospital system. Crislip hosts the QuackCast podcast. He also produces two other podcasts, has written and edited several books, and regularly writes for medicine-related blogs. He is a co-founder of the Institute for Science in Medicine as well as a co-founder and the current president of the Society for Science-Based Medicine.