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A comprehensive textbook "Transgender Medicine - Multidisciplinary Approach" co-edited by Leonid Poretsky, MD and Wylie Hembree, MD was published in 2019 (Springer Publishers, Inc.)

Poretsky had been researching the causes of hyperandrogenism (high level of male hormones and male features in females) in patients with extreme forms of insulin resistance, for example in people with insulin receptor gene mutations. Subsequently, Poretsky’s work became important for understanding more common disorders, such as polycystic ovary syndrome (PCOS), which affects up to 10% of reproductive age women and is associated with infertility and diabetes. Poretsky’s work helped lead to the use of insulin-sensitizing agents in patients with PCOS.

Poretsky’s other publications address a variety of subjects in diabetes and reproduction. Recent publications include an invited editorial in the Proceedings of the National Academy of Sciences on the role of advanced glycation end products (AGEs) in metabolic disease; a study of the potential new treatment for prevention of diabetic nephropathy (carried out in collaboration with investigators from the Mount Sinai School of Medicine); a review of the role of Vitamin D in human reproduction; and an editorial on the problem of recurrent hospitalizations of patients with diabetes.

In September 2014, Dr. Poretsky joined the staff of Lenox Hill Hospital as its Chief of the Division of Endocrinology. He is leading the effort to develop academic and clinical programs. An endocrinology fellowship program was initiated in July 2016 and a new site for the Gerald J. and Dorothy R. Friedman Diabetes Institute at Lenox Hill Hospital opened on August 1, 2016. Another specialized program in the division--Friedman Transgender Health and Wellness Program--opened in 2017.[2] The division has numerous grants from philanthropic organizations, industry and government agencies (New York State Department of Health and the National Institutes of Health). Lenox Hill Hospital is a part of Northwell Health, formerly North Shore – LIJ Health System, a network of hospitals, nursing homes, a medical school, a nursing school, a medical research institute, ambulatory care centers, urgent care centers, a health insurance company, and laboratories.

As of 2014 he is a professor of medicine at Hofstra Northwell School of Medicine in Hempstead, New York, and Chief of the Division of Endocrinology at Lenox Hill Hospital in Manhattan, New York.

In 2013 he published a letter in the Wall Street Journal talking about inadequate methods used by the government to assess hospital performance and a letter regarding policy changes needed to reduce hospital readmissions. In 2017, he published a letter about Medicare being allowed to compete with private health insurance plans.

In 2012 he edited Diabetes Mellitus: A Concise Clinical Guide, which covers "the basics of diagnosis, complications, therapies and prevention of diabetes." The book consists of sections originally published in the second edition of Principles of Diabetes Mellitus.

He contributed to and edited the comprehensive textbook Principles of Diabetes Mellitus, which has been widely cited, and has gone through three editions so far (2002, 2010 and 2017). The book covers a wide range of topics on diabetes.

While at Beth Israel Medical Center (2000 - 2014), Dr. Poretsky served as Chief of the Division of Endocrinology, Vice-Chairman for Research, and Interim Chairman in the Department of Medicine. He held the Gerald J. Friedman endowed chair in endocrinology and metabolism at Beth Israel Medical Center and was a founding director of the Gerald J. Friedman Diabetes Institute.

Poretsky has been vocal in the media about how health care policy can affect patient care. In the 1990s he wrote a letter to the editor of New York Times concerning how Medicaid payment caps can limit physicians' availability to patients. In July 2012 he wrote an op-ed for Forbes which drew comparisons between the bureaucratic behavior of the American healthcare system and that of the Soviet Union's, which he says "collapsed under the weight of its own bureaucratic inefficiencies two decades ago." This article was followed by a scholarly publication on the subject entitled “The sovietization of American medicine: Notes from the front lines”, which appeared in Journal in American Physicians and Surgeons, 2013.

Additionally, in 1987 Poretsky was a key member of the team which described a condition called hyporeninemic hypoaldosteronism, which is characterized by deficiency of adrenal hormone aldosterone, in patients with AIDS. This discovery resulted in introduction of treatment with fludrocortisone, which proved to be extremely effective and almost immediately converted most patients with this condition from being unable to stand (because of a severe drop in blood pressure upon standing) to being mobile and more functional.

While working as a research fellow at Harvard in the early 1980s, Poretsky became known for discovering, describing and characterizing insulin receptors in the human ovary.

He immigrated with his family to the United States in 1979. Upon completing his internal medicine residency program, he began a fellowship in endocrinology and metabolism at Boston’s Beth Israel Hospital (now Beth Israel/Deaconess Medical Center). He also completed a research fellowship in medicine at Harvard Medical School (1983–1985), where he was mentored by Dr. Jeffrey Flier.

Leonid Poretsky (born August 7, 1954) is a Russian-born American endocrinologist. His research interests include mechanisms of insulin action in the ovary, endocrinological aspects of AIDS, and clinical outcomes in diabetes. He has authored over 100 publications and has served on the National Institutes of Health's review committees and on the editorial boards of the Journal of Clinical Endocrinology and Metabolism and other endocrine journals.

Leonid Poretsky was born on August 7, 1954 in Leningrad, Russian SSR. His mother, Nina, was a well known pediatrician from Bobruisk, Belarus who lived and worked in Leningrad. His father was a prominent engineer. Poretsky graduated from First (Pavlov) Medical Institute in Leningrad (now St. Petersburg State Medical University), cum laude in 1977.